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    • Upstream Bio Inc. logo

    Upstream Bio Inc.

    UPB | NASDAQ
    Chart Builder DCF Calculator
    $5.37
    +$0.03 (+0.56%)
    At close: Sep 21, 2026, 4:00 PM ET
    $5.37
    $0 (-0.09%)
    After-hours: Sep 21, 2026, 7:30 PM ET
    Overview Rating Statistics Financials Earnings Analysts Ownership Profile

    Market Data

    Market Cap
    $290.6M
    Enterprise Value
    $31.61M
    Beta
    1.29
    Average Volume
    593.06K
    Shares Outstanding (Diluted)
    54.57M
    Shares Change YoY
    1.48%
    Institutional Ownership
    82.61%
    Exchange
    NASDAQ
    ISIN
    US91678A1079

    Price Performance

    Price Change 1M
    -21.9%
    Price Change 3M
    -15.0%
    Price Change 6M
    -43.3%
    Price Change YTD
    -80.2%
    Price Change 1Y
    -67.8%
    Price Change 3Y
    -75.6%
    Price Change 5Y
    -75.6%
    1M CAGR (ann.)
    -22.3%
    1Y CAGR (ann.)
    -66.7%
    5Y CAGR (ann.)
    N/A
    All-Time CAGR
    -51.9%

    Valuation

    PE Ratio
    -1.85
    Forward PE
    N/A
    PEG Ratio
    0.06
    Forward PEG
    0.48
    PS Ratio
    92.45
    Forward PS
    178.60
    PB Ratio
    1.08
    P/FCF Ratio
    -2.14
    P/Adj. FCF Ratio
    -1.94
    P/OCF Ratio
    -2.15
    EV/Sales
    10.01
    EV/EBIT
    -0.20
    EV/EBITDA
    -0.20
    EV/FCF
    -0.23
    Earnings Yield
    -54.0%
    FCF Yield
    -46.7%
    Adj. FCF Yield
    -51.5%

    Financial Health

    Net Cash
    $260.35M
    Total Debt
    $954K
    Cash & Short-Term Investments
    $261.31M
    Total Assets
    $281.17M
    Current Ratio
    27.99
    Quick Ratio
    27.99
    Debt / Equity Ratio
    0.00
    Debt / EBITDA
    -0.01
    Debt / FCF
    -0.01
    OCF / Debt
    -142.92
    Interest Coverage
    0.00
    Altman Z-Score
    14.33
    Piotroski F-Score
    2

    Margins & Profitability

    Gross Profit Margin
    98.5%
    Operating Profit Margin
    -5382.6%
    EBITDA Margin
    -4950.9%
    Net Profit Margin
    -4955.7%
    FCF Margin
    -4317.4%
    Adj. FCF Margin
    -4763.9%
    SBC / Revenue
    446.5%
    SBC Impact (per share)
    -10.3%

    Returns

    Return on Assets
    -55.7%
    Return on Equity
    -48.4%
    Return on Invested Capital
    -62.5%
    Return on Capital Employed
    -62.7%
    Return on Tangible Assets
    -55.7%

    Historical Growth (CAGR)

    Revenue CAGR 3Y
    33.0%
    Revenue CAGR 5Y
    N/A
    Revenue CAGR 10Y
    N/A
    EPS CAGR 3Y
    -46.4%
    EPS CAGR 5Y
    N/A
    EPS CAGR 10Y
    N/A
    FCF CAGR 3Y
    -61.8%
    FCF CAGR 5Y
    N/A
    FCF CAGR 10Y
    N/A

    Analyst Forecasts

    Analyst Rating
    Buy
    Analyst Count
    5
    EPS Growth Next 3Y
    -3.6%
    Revenue Growth Next 3Y
    45.4%
    Earnings Date
    Nov 3, 2026
    EPS Estimate (next Q)
    -$0.73
    EPS Growth Est (next Q)
    15.7%
    Revenue Est (next Q)
    $522.46K
    Revenue Growth Est (next Q)
    -23.5%

    Fair Value Estimates

    Graham Number
    N/A
    Graham Upside
    N/A
    Lynch Fair Value
    N/A
    Lynch Upside
    N/A
    Price Target
    $20
    Price Target Upside
    272.4%

    Cash Flow

    Operating Cash Flow
    $-136.34M
    Free Cash Flow
    $-136.34M
    Adj. Free Cash Flow
    $-150.45M
    FCF Per Share
    -$2.50
    OCF Per Share
    -$2.50
    OCF/S Ratio
    -4317.4%

    Income Statement

    Revenue
    $3.16M
    Gross Profit
    $3.11M
    Operating Income
    $-169.98M
    EBITDA
    $-156.35M
    Net Income
    $-156.5M
    EPS (Diluted)
    -$2.90
    Revenue / Employee
    $42.11K
    Profit / Employee
    $-2.09M
    Employees
    75

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