Upstream Bio Inc.
UPB | NASDAQ
$5.37
+$0.03 (+0.56%)
At close: Sep 21, 2026, 4:00 PM ET
$5.37
$0 (-0.09%)
After-hours:
Sep 21, 2026, 7:30 PM ET
Institutional Ownership
Net OutflowTotal Institutions
145
Total Ownership
82.61%
Capital Flow
-$984.96M
Shares Change
-6.29M
Ownership Distribution
Institutions (82.61%)
Others (17.39%)
Institutional Sentiment
Overall: neutralEquity Sentiment & Activity
bullishNew Positions
46
Increased Positions
95
Reduced Positions
35
Closed Positions
40
New (46)
Increased (95)
Reduced (35)
Closed (40)
Options Sentiment & Activity
bearishPut/Call Ratio
1.155
Call Flow
70,200
Put Flow
81,100
Calls (46%)
Puts (54%)
Super Investors
| Super Investor / Fund | Ownership | Portfolio Weight | Shares | Market Value | |
|---|---|---|---|---|---|
| Point72 Asset Management LP | 0.33% 0.00% | < 0.01% | 178.17K | 1.23M | |
| Tudor Investment Corp ET AL | 0.05% 0.00% | < 0.01% | 26.41K | 182.51K |
Top Shareholders
| Institution | Ownership | Portfolio Weight | Shares | Market Value | |
|---|---|---|---|---|---|
| FMR LLC | 14.91% +6.81% | < 0.01% -63.10% | 8.1M +7.76% | 72.91M -64.28% | |
| Orbimed Advisors LLC | 10.48% -0.88% | 1.02% -67.80% | 5.69M 0.00% | 51.24M -66.85% | |
| Blackrock, Inc. | 6.20% -0.11% | < 0.01% -65.47% | 3.37M +0.78% | 30.34M -66.59% |
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