Ionis Pharmaceuticals Inc.
IONS | NASDAQ
$45.50
+$0.60 (+1.34%)
Sep 22, 2026, 1:15 PM ET · Market open
Market Data
Market Cap $7.46B
Enterprise Value $7.83B
Beta 0.42
Average Volume 2.64M
Shares Outstanding (Diluted) 165.42M
Shares Change YoY -9.28%
Institutional Ownership N/A
Exchange NASDAQ
ISIN US4622221004
Price Performance
Price Change 1M -25.8%
Price Change 3M -40.9%
Price Change 6M -38.2%
Price Change YTD -43.6%
Price Change 1Y -26.8%
Price Change 3Y 5.1%
Price Change 5Y 24.0%
1M CAGR (ann.) -20.6%
1Y CAGR (ann.) -27.3%
5Y CAGR (ann.) 4.4%
All-Time CAGR 8.9%
Valuation
PE Ratio -12.98
Forward PE N/A
PEG Ratio 0.16
Forward PEG 0.29
PS Ratio 8.54
Forward PS 5.60
PB Ratio 16.97
P/FCF Ratio -13.35
P/Adj. FCF Ratio -10.99
P/OCF Ratio -14.97
EV/Sales 8.96
EV/EBIT -15.59
EV/EBITDA 1.81
EV/FCF -14.00
Earnings Yield -7.7%
FCF Yield -7.5%
Adj. FCF Yield -9.1%
Financial Health
Net Debt $101.42M
Total Debt $2.42B
Cash & Short-Term Investments $2.05B
Total Assets $2.99B
Current Ratio 7.88
Quick Ratio 7.72
Debt / Equity Ratio 5.50
Debt / EBITDA 0.56
Debt / FCF -4.33
OCF / Debt -0.21
Interest Coverage -6.65
Altman Z-Score 1.04
Piotroski F-Score 2
Margins & Profitability
Gross Profit Margin 98.2%
Operating Profit Margin -68.1%
EBITDA Margin 495.6%
Net Profit Margin -64.6%
FCF Margin -64.0%
Adj. FCF Margin -77.7%
SBC / Revenue 13.7%
SBC Impact (per share) -21.5%
Returns
Return on Assets -18.9%
Return on Equity -110.8%
Return on Invested Capital -20.4%
Return on Capital Employed -22.2%
Return on Tangible Assets -18.9%
Historical Growth (CAGR)
Revenue CAGR 3Y 11.5%
Revenue CAGR 5Y 4.9%
Revenue CAGR 10Y 17.4%
EPS CAGR 3Y -18.0%
EPS CAGR 5Y -28.4%
EPS CAGR 10Y -43.6%
FCF CAGR 3Y -22.6%
FCF CAGR 5Y -33.0%
FCF CAGR 10Y -131.4%
Analyst Forecasts
Analyst Rating Buy
Analyst Count 33
EPS Growth Next 3Y 58.2%
Revenue Growth Next 3Y 41.5%
Earnings Date Nov 3, 2026
EPS Estimate (next Q) -$1
EPS Growth Est (next Q) 63.9%
Revenue Est (next Q) $181.81M
Revenue Growth Est (next Q) 16.0%
Fair Value Estimates
Graham Number N/A
Graham Upside N/A
Lynch Fair Value N/A
Lynch Upside N/A
Price Target $86.25
Price Target Upside 92.1%
Cash Flow
Operating Cash Flow $-496.43M
Free Cash Flow $-558.88M
Adj. Free Cash Flow $-678.89M
FCF Per Share -$3.38
OCF Per Share -$3
OCF/S Ratio -56.8%
Income Statement
Revenue $873.76M
Gross Profit $857.7M
Operating Income $-594.9M
EBITDA $4.33B
Net Income $-564.78M
EPS (Diluted) -$3.46
Revenue / Employee $590.38K
Profit / Employee $-381.61K
Employees 1,480
Add to Watchlist
Select watchlists to add or remove IONS